منابع مشابه
Leukemia and Benzene
Excessive exposure to benzene has been known for more than a century to damage the bone marrow resulting in decreases in the numbers of circulating blood cells, and ultimately, aplastic anemia. Of more recent vintage has been the appreciation that an alternative outcome of benzene exposure has been the development of one or more types of leukemia. While many investigators agree that the array o...
متن کاملBenzene and leukemia.
Dear Editors: Although there were numerous case reports showing the possible role of benzene in the development of leu-kemia, the first epidemiologic study on this problem appeared in 1974 (1). From 1967 to September 1973,26 patients with leukemia were investigated among 28,500 shoe, slipper, and handbag workers chronically exposed to benzene in Istanbul, Turkey. Seventeen of them were studied ...
متن کاملBenzene and leukemia: an epidemiologic risk assessment.
To assess quantitatively the association between benzene exposure and leukemia, we examined the mortality rate of a cohort with occupational exposure to benzene. Cumulative exposure for each cohort member was estimated from historical air-sampling data and, when no sampling data existed, from interpolation on the basis of existing data. The overall standardized mortality ratio (a measure of rel...
متن کاملAssociation between Urban Benzene Pollution and Incidence of Acute Myeloid Leukemia
Background: Benzene has been classified as group 1 human carcinogens in the environment by the International Agency for Research on Cancer (IARC) mainly because of its ability to cause acute myeloid leukemia (AML). This study was conducted to detect any probable association between urban benzene pollution concentration and occurrence of AML in different regions of Tehran. Methods: In thi...
متن کاملBenzene, the exposome and future investigations of leukemia etiology.
Benzene exposure is associated with acute myeloid leukemia (AML), myelodysplastic syndromes (MDS), and probably lymphoma and childhood leukemia. Biological plausibility for a causal role of benzene in these diseases comes from its toxicity to hematopoietic stem cells (HSC) or progenitor cells, from which all leukemias and related disorders arise. The effect of this toxicity is manifest as lower...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1991
ISSN: 0091-6765
DOI: 10.2307/3430992